SH*abnormalities (Subheading) LA; ; ; ; ; ; ; ; ; ; ; MSUsed with organs for congenital defects producing changes in the morphology of the organ. OLsearch policy: Online Manual; use: main heading/AB or AB (SH) or SUBS APPLY AB ANsubhead only; congenital & structural only: does not include abnormal function ( = /physiopathology or disease heading); includes ╥deformity╙, ╥malformation╙, ╥anomalous╙, ╥teratology╙; includes agenesis, aplasia, atresia, ectopy, hypoplasia, etc.; includes more or less than the normal number of organs (as one ureter, six fingers); see MeSH scope note in Introduction; indexing policy: Manual 19.4.1; DF: /abnorm or /AB LT LQ SH*administration & dosage (Subheading) LA MSUsed with drugs for dosage forms, routes of administration, frequency and duration of administration, quantity of medication, and the effects of these factors. OLsearch policy: Online Manual; use: main heading/AD or AD (SH) or SUBS APPLY AD ANsubhead only; for routes of administration, timing, amounts of doses; not for ╥dosage╙ in Romance languages ( = /analysis) ; see MeSH scope note in Introduction; indexing policy: Manual 19.4.2; DF: /admin or /AD LT LQ SH*adverse effects (Subheading) LA; ; ; ; ; MSUsed with drugs, chemicals, or biological agents in accepted dosage, - or with physical agents or manufactured products in normal usage, - when intended for diagnostic, therapeutic, prophylactic or anesthetic purposes. Used also for adverse effects or complications of diagnostic, therapeutic, prophylactic, anesthetic, surgical, or other procedures. OLsearch policy: Online Manual; use: main heading/AE or AE (SH) or SUBS APPLY AE ANsubhead only; includes ╥injurious effects╙, ╥undesirable effects ╙, ╥side effects╙ in normal use; for complications following various procedures; see also /poisoning & /toxicity ; see MeSH scope note in Introduction; indexing policy: Manual 19.4.3; DF: /adv eff or /AE LT LQ SH*analogs & derivatives (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed with drugs and chemicals for substances that share the same parent molecule or have similar electronic structure but differ by the addition or substitution of other atoms or molecules. Used when the specific chemical heading is not available, and no appropriate group heading exists. OLsearch policy: Online Manual; use: main heading/AA or AA (SH) or SUBS APPLY AA ANsubhead only; includes ╥related compounds╙, ╥simulants╙; do not use with elements, isotopes, plural chemicals or enzymes; see MeSH scope note in Introduction; indexing policy: Manual 19.4.4; DF: /analogs or /AA LT LQ SH*analysis (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed for the identification or quantitative determination of a substance or its constituents and metabolites; includes the chemical analysis of tissues, tumors, body fluids, organisms, plants, air, water, or other environmental carrier. Applies to both methodology and results. For analysis of substances in blood, cerebrospinal fluid, and urine the specific subheading designating the fluid is used. OLsearch policy: Online Manual; use: main heading/AN or AN (SH) or SUBS APPLY AN ANsubhead only; includes ╥assay╙, ╥determination╙, ╥chemical analysis╙; for qualitative or quantitative analysis of substances; for chemical composition of organs & organisms, as ╥chemical composition of the liver╙ = LIVER /analysis; for analysis of chemical substances in the blood use /blood; in the cerebrospinal fluid, use /cerebrospinal fluid; in the urine, use /urine; see MeSH scope note in Introduction; indexing policy: Manual 19.4.5; DF: /anal or /AN LT LQ SH*anatomy & histology (Subheading) LA; ; ; ; MSUsed with organs, regions, and tissues for normal descriptive anatomy and histology; used for normal anatomy and structure of animals and plants. OLsearch policy: Online Manual; use: main heading/AH or AH (SH) or SUBS APPLY AH ANsubhead only; includes ╥morphology╙; normal structure only; for disordered structural change use /pathology; see also /cytology & /ultrastructure; see also /blood supply & /innervation; see also /abnormalities; see MeSH scope note in Introduction; indexing policy: Manual 19.4.6; DF: /anat or /AH LT LQ SH*antagonists & inhibitors (Subheading) LA MSUsed with chemicals, drugs, and endogenous substances to indicate substances or agents which counteract their biological effects by any mechanism. OLsearch policy: Online Manual; use: main heading/AI or AI (SH) or SUBS APPLY AI ANsubhead only; for exogenous & endogenous substances; see MeSH scope note in Introduction; indexing policy: Manual 19.4.7; DF: /antag or /AI LT LQ SH*biosynthesis (Subheading) LA MSUsed for the formation of chemical substances in organisms, in living cells, or by subcellular fractions. OLsearch policy: Online Manual; use: main heading/BI or BI (SH) or SUBS APPLY BI ANsubhead only; includes ╥formation╙ & ╥production╙ of substances by living tissue or organisms; see MeSH scope note in Introduction; indexing policy: Manual 19.4.8; DF /biosyn or /BI LT LQ SH*blood (Subheading) LA; ; ; ; ; ; ; ; ; MSUsed for the presence or analysis of substances in the blood; also for examination of, or changes in, the blood in disease states. Excludes serodiagnosis, for which the subheading ╥diagnosis╙ is used, and serology, for which ╥immunology╙ is used. OLsearch policy: Online Manual; use: main heading/BL or BL (SH) or SUBS APPLY BL ANsubhead only; for ╥in blood╙ or ╥blood in╙ animals or diseases; includes the presence of cells, coagulating elements, endogenous & exogenous chemical substances; not for ╥serology╙ ( = /immunology), nor for ╥serodiagnosis╙ ( = /diagnosis), nor for the presence of microbes or parasites in the blood in disease ( = /microbiology or /parasitology); see MeSH scope note in Introduction; indexing policy: Manual 19.4.9; DF: /blood or /BL LT LQ SH*blood supply (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed for arterial, capillary, and venous systems of an organ or region whenever the specific heading for the vessel does not exist; includes blood flow through the organ. OLsearch policy: Online Manual; use: main heading/BS or BS (SH) or SUBS APPLY BS ANsubhead only; includes arteries, veins, capillaries & microvasculature; covers vascular anatomy, circulation & pressure; see MeSH scope note in Introduction; indexing policy: Manual 19.4.10; DF: /blood supply or /BS LT LQ SH*cerebrospinal fluid (Subheading) LA; ; ; ; ; ; ; ; ; MSUsed for the presence or analysis of substances in the cerebrospinal fluid; also for examination of or changes in cerebrospinal fluid in disease states. OLsearch policy: Online Manual; use: main heading/CF or CF (SH) or SUBS APPLY CF ANsubhead only; for ╥in cerebrospinal fluid╙ or ╥cerebrospinal fluid in╙ animals or diseases; includes the presence of cells & endogenous & exogenous chemical substances; not for the presence of microbes or parasites in the cerebrospinal fluid in disease ( = /microbiology or /parasitology); see MeSH scope note in Introduction; indexing policy: Manual 19.4.11; DF: /csf or /CF LT LQ SH*chemical synthesis (Subheading) LA MSUsed for the chemical preparation of molecules in vitro. For the formation of chemical substances in organisms, living cells, or subcellular fractions, ╥biosynthesis╙ is used. OLsearch policy: Online Manual; use: main heading/CS or CS (SH) or SUBS APPLY CS ANsubhead only; for chemical preparation or production of substances in vitro only, in laboratories or industry; not for formation of substances in living tissue ( = /biosynthesis); see MeSH scope note in Introduction; indexing policy: Manual 19.4.12; DF: /chem syn or /CS LT LQ SH*chemically induced (Subheading) LA; MSUsed for diseases, syndromes, congenital abnormalities, or symptoms caused by chemical compounds in man or animals. OLsearch policy: Online Manual; use: main heading/CI or CI (SH) or SUBS APPLY CI ANsubhead only; for diseases induced by exogenous substances only; see MeSH scope note in Introduction; indexing policy: Manual 19.4.13; DF: /chem ind or /CI LT LQ SH*classification (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed for taxonomic or other systematic or hierarchical classification systems. OLsearch policy: Online Manual; use: main heading/CL or CL (SH) or SUBS APPLY CL ANsubhead only; includes ╥taxonomy╙, ╥systematics╙, ╥hierarchies╙; indexing policy: Manual 19.4.14; DF: /class or /CL LT LQ SH*complications (Subheading) LA; MSUsed with diseases to indicate conditions that co-exist or follow, i.e. co-existing diseases, complications, or sequelae. OLsearch policy: Online Manual; use: main heading/CO or CO (SH) or SUBS APPLY CO ANsubhead only; includes ╥sequelae╙; also for ╥co-existent╙ or ╥associated╙ diseases; see MeSH scope note in Introduction; indexing policy: Manual 19.4.15; DF: /compl or /CO LT LQ SH*congenital (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed with disease headings to indicate those conditions existing at, and usually before birth; excludes morphologic abnormalities and birth injuries, for which ╥abnormalities╙ and ╥injuries╙ are used. OLsearch policy: Online Manual; use: main heading/CN or CN (SH) or SUBS APPLY CN ANsubhead only; diseases existing at or before birth; not for structural abnormalities ( = /abnormalities) nor for birth injuries ( = /injuries); indexing policy: Manual 19.4.16; DF: /congen or /CN LT LQ SH*cytology (Subheading) LA; ; ; ; ; MSUsed for normal cellular morphology of unicellular and multicellular organisms. OLsearch policy: Online Manual; use: main heading/CY or CY (SH) or SUBS APPLY CY ANsubhead only; normal structure only; for non-normal, use /pathology; includes cellular & intracellular structure, morphology, multiplication, cell cycle, differentiation, etc.; see also /ultrastructure; see MeSH scope note in Introduction; indexing policy: Manual 19.4.17; DF: /cytol or /CY LT LQ SH*deficiency (Subheading) LA MSUsed with endogenous and exogenous substances which are absent or in diminished amount relative to the normal requirement of an organism or a biologic system. OLsearch policy: Online Manual; use: main heading/DF or DF (SH) or SUBS APPLY DF ANsubhead only; for deficient or inadequate intake or biosynthesis; also for deficient secretion of endogenous substances; see MeSH scope note in Introduction; indexing policy: Manual 19.4.18; /DF: /defic or DF LT LQ SH*diagnosis (Subheading) LA; MSUsed with diseases for all aspects of diagnosis, including examination, differential diagnosis and prognosis; excludes mass screening for which ╥prevention & control╙ is used. The subheading ╥radiography╙ is used for radiographic diagnosis. OLsearch policy: Online Manual; use: main heading/DI or DI (SH) or SUBS APPLY DI ANsubhead only; includes ╥examination╙, ╥symptoms╙, ╥differential diagnosis╙; not for X-ray diagnosis ( = /radiography), nor for radioisotope scanning ( = /radionuclide imaging), nor for mass screening ( = prevention & control); indexing policy: Manual 19.4.19; DF: /diag or /DI LT LQ SH*diagnostic use (Subheading) LA; MSUsed with chemical compounds, drugs, and physical agents when used for studies of clinical function of an organ, or for the diagnosis of human or animal diseases. OLsearch policy: Online Manual; use: main heading/DU or DU (SH) or SUBS APPLY DU ANsubhead only; for substances & physical agents used in diagnosis of disease or study of organ function; see MeSH scope note in Introduction; indexing policy: Manual 19.4.20; DF: /diag use or /DU LT LQ SH*diet therapy (Subheading) LA; MSUsed with disease headings for dietary and nutritional management of the disease. Does not include vitamin or mineral supplements, for which ╥drug therapy╙ may be used. OLsearch policy: Online Manual; use: main heading/DH or DH (SH) or SUBS APPLY DH ANsubhead only; for dietary & nutritional management of a disease by a physician; not for self diets; not for vitamin or mineral supplements prescribed by a physician ( = /drug therapy); indexing policy: Manual 19.4.2l; DF: /diet ther or /DH LT LQ SH*drug effects (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed with organs, regions, tissues, or organisms and physiological and psychological processes for the effects of drugs and chemicals. OLsearch policy: Online Manual; use: main heading/DE or DE (SH) or SUBS APPLY DE ANsubhead only; for effect of exogenously administered drugs & chemicals; includes their mechanism of action; see MeSH scope note in Introduction; indexing policy: Manual 19.4.22; DF: /drug eff or /DE LT LQ SH*drug therapy (Subheading) LA; MSUsed with disease headings for the treatment of the disease by the administration of drugs, chemicals, and antibiotics. For diet therapy and radiotherapy, use specific subheadings. Excludes immunotherapy and treatment with biologicals for which ╥therapy╙ is used. OLsearch policy: Online Manual; use: main heading/DT or DT (SH) or SUBS APPLY DT ANsubhead only; includes treatment or prevention by drugs & chemicals; includes therapy with antibiotics; not for immunotherapy ( = /therapy) nor for tissue therapy or therapy with biological products ( = /therapy); see MeSH scope note in Introduction; indexing policy: Manual 19.4.23; DF: /drug ther or /DT LT LQ SH*economics (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; MSUsed for the economic aspects of any subject, as well as for all aspects of financial management. Includes the raising or providing of funds. OLsearch policy: Online Manual; use: main heading/EC or EC (SH) or SUBS APPLY EC ANsubhead only; includes ╥finances╙, ╥financing╙, ╥funding╙, ╥costs╙, ╥fees╙, ╥salaries╙, ╥financial management╙, etc.; see MeSH scope note in Introduction; indexing policy: Manual 19.4.69; DF: /econ or /EC LT LQ SH*education (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; MSUsed for education and training programs in various fields and disciplines, and for training groups of persons. OLsearch policy: Online Manual; use: main heading/ED or ED (SH) or SUBS APPLY ED ANsubhead only; includes ╥training╙, ╥teaching╙, ╥curriculum╙; for the teacher teaching, the student learning & the courses taught; see MeSH scope note in Introduction; indexing policy: Manual 19.4.24; DF: /educ or /ED LT LQ SH*embryology (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed with organs, regions, and animal headings for embryologic and fetal development; also used with diseases for embryologic factors contributing to postnatal disorders. OLsearch policy: Online Manual; use: main heading/EM or EM (SH) or SUBS APPLY EM ANsubhead only; includes ╥embryonic╙, ╥embryonal╙, ╥embryological aspects╙; for embryonic & fetal development; see MeSH scope note in Introduction; indexing policy: Manual 19.4.25; DF: /embryol or /EM LT LQ SH*enzymology (Subheading) LA; ; ; ; ; ; ; MSUsed with organisms, except vertebrates, and with organs and tissues, also used, with diseases, for enzymes during the course of the disease. Excludes diagnostic enzyme tests, for which ╥diagnosis╙ is used. OLsearch policy: Online Manual; use: main heading/EN or EN (SH) or SUBS APPLY EN ANsubhead only; for enzymatic metabolism, kinetics, analysis & inhibition; not for enzyme tests ( = /diagnosis); see MeSH scope note in Introduction; indexing policy: Manual 19.4.26; DF: /enzymol or /EN LT LQ SH*ethnology (Subheading) LA; ; ; ; ; ; ; ; MSUsed with diseases for ethnic or racial aspects, and with geographic headings to indicate the place of origin of a group of people. OLsearch policy: Online Manual; use: main heading/EH or EH (SH) or SUBS APPLY EH ANsubhead only; with disease & selected terms for ╥the place of origin of a group of people╙; with geog terms for the place of origin of people living outside their native land, as New York City Cubans ( = CUBA/ethnology); indexing policy: Manual 19.4.27; DF: /ethnol or /EH LT LQ SH*etiology (Subheading) LA; MSUsed with diseases for causative agents including microorganisms; includes environmental and social factors and personal habits as contributing factors; includes pathogenesis. OLsearch policy: Online Manual; use: main heading/ET or ET (SH) or SUBS APPLY ET ANsubhead only; includes ╥pathogenesis╙ & ╥causes╙; see MeSH scope note in Introduction; indexing policy: Manual 19.4.28; DF: /etiol or /ET LT LQ SH*familial & genetic (Subheading) LA; MSUsed for studies of genetic basis of disease; studies of diseases occurring in family groups due to environmental factors including infection, and common family dietary habits; includes hereditary disease. OLsearch policy: Online Manual; use: main heading/FG or FG (SH) or SUBS APPLY FG ANsubhead only; includes ╥hereditary╙; with diseases only; see also /genetics; see MeSH scope note in Introduction; indexing policy: Manual 19.4.29; DF: /familial or /FG LT LQ SH*genetics (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed for studies of the mechanisms of heredity in organisms, or genetic aspects of endogenous chemicals. OLsearch policy: Online Manual; use: main heading/GE or GE (SH) or SUBS APPLY GE ANsubhead only; includes ╥heredity╙; with organisms for genetic discussions; with endogenous chemicals only for their genetic aspects; for genetic aspects of disease use /familial & genetic; indexing policy: Manual 19.4.70; DF: /genet or /GE LT LQ SH*growth & development (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed with microorganisms, plants, and the postnatal period of animals for growth and development; includes postnatal growth or development of organs or anatomical parts. OLsearch policy: Online Manual; use: main heading/GD or GD (SH) or SUBS APPLY GD ANsubhead only; for micro-organisms & plants; with animals, for postnatal development only: for prenatal development, see /embryology; see MeSH scope note in Introduction; indexing policy: Manual 19.4.30; DF: /growth or /GD LT LQ SH*history (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed for the historical aspects of any subject; includes brief historical notes. Excludes case histories. OLsearch policy: Online Manual; use: main heading/HI or HI (SH) or SUBS APPLY HI ANsubhead only; for historical articles or historical notes in articles; not for ╥case histories╙ ( = check tag CASE REPORT); see MeSH scope note in Introduction; indexing policy: Manual 19.4.31; DF: /hist or /HI LT LQ SH*immunology (Subheading) LA; ; ; ; ; ; ; ; ; ; MSUsed for immunologic studies of tissues, organs, microorganisms, fungi, viruses, and animals; includes immunologic aspects of diseases but not immunologic procedures used for diagnostic, preventive, or therapeutic purposes, for which ╥diagnosis╙, ╥prevention & control╙, or ╥therapy╙ are used. Also used for chemicals as antigens or haptens. OLsearch policy: Online Manual; use: main heading/IM or IM (SH) or SUBS APPLY IM ANsubhead only; for ╥immunological aspects╙ or ╥serological aspects╙; for substances as antigens or haptens; for antibodies to substances, organs or organisms; not for immunotherapy ( = /therapy), nor for immunologic prevention, as with vaccines ( = /prevention & control), nor for serodiagnosis ( = /diagnosis); see MeSH scope note in Introduction; indexing policy: Manual 19.4.32; DF: /immunol or /IM LT LQ SH*in adolescence (Subheading) LA; ; ; MSUsed for occurrence during adolescence, 13 to 18 years of age. OLsearch policy: CATLINE, AVLINE only; Online Manual; use: main heading/AO or SUBS APPLY AO ANsubhead only; for catalogers only; covers ages 13 to 18 years; indexers use check tag ADOLESCENCE (see Manual 18.5) LT LQ SH*in adulthood (Subheading) LA; ; ; MSUsed for occurrence during adulthood, 19 to 44 years of age. OLsearch policy: CATLINE, AVLINE only; Online Manual; use: main heading/AU or SUBS APPLY AU ANsubhead only; for catalogers only; covers ages 19 to 44 years; indexers use check tag ADULT (see Manual 18.5) LT LQ SH*in infancy & childhood (Subheading) LA; ; ; MSUsed for occurrence during infancy and childhood, birth to 12 years of age. OLsearch policy: CATLINE, AVLINE only; Online Manual; use: main heading/IC or SUBS APPLY IC ANsubhead only; for catalogers only; covers ages 0 to 12 years; indexers use check tags INFANT; INFANT, NEWBORN; CHILD; CHILD, PRESCHOOL (see Manual 18.5) LT LQ SH*in middle age (Subheading) LA; ; ; MSUsed for occurrence during middle age, 45 to 64 years of age. OLsearch policy: CATLINE, AVLINE only; Online Manual; use: main heading/MY or SUBS APPLY MY ANsubhead only; for catalogers only; covers ages 45 to 64 years; indexers use check tag MIDDLE AGE (see Manual 18.5) LT LQ SH*in old age (Subheading) LA; ; ; MSUsed for occurrence during old age, 65 years of age and older. OLsearch policy: CATLINE, AVLINE only; Online Manual; use: main heading/OA or SUBS APPLY OA ANsubhead only; for catalogers only; covers ages 65 years & older; indexers use check tag AGED (see Manual 18.5) LT LQ SH*in pregnancy (Subheading) LA; ; ; MSUsed for occurrence during pregnancy. OLsearch policy: CATLINE, AVLINE only; Online Manual; use: main heading/PR or SUBS APPLY PR ANsubhead only; for catalogers only; indexers use check tag PREGNANCY (see Manual 18.4) LT LQ SH*injuries (Subheading) LA; ; ; ; ; ; ; ; ; ; ; MSUsed with anatomic headings for wounds and injuries. Excludes cell damage, for which ╥pathology╙ is used. OLsearch policy: Online Manual; use: main heading/IN or IN (SH) or SUBS APPLY IN ANsubhead only; by physical trauma only; includes ╥wounds╙, ╥trauma╙; for ╥lesion╙ in Romance languages; not for cell damage ( = /pathology); indexing policy: Manual 19.4.33; DF: /inj or /IN LT LQ SH*innervation (Subheading) LA; ; ; ; ; ; ; ; ; ; ; MSUsed with organs, regions, or tissues for their nerve supply. OLsearch policy: Online Manual; use: main heading/IR or IR (SH) or SUBS APPLY IR ANsubhead only; includes ╥nerve supply╙; see MeSH scope note in Introduction; indexing policy: Manual 19.4.34; DF: /innerv or /IR LT LQ SH*instrumentation (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed with diagnostic or therapeutic procedures, analytic technics, and specialties or disciplines, for the development or modification of apparatus, instruments, or equipment. OLsearch policy: Online Manual; use: main heading/IS or IS (SH) or SUBS APPLY IS ANsubhead only; includes ╥apparatus╙, ╥appliances╙, ╥instruments╙,╥equipment╙, ╥supplies╙, ╥devices╙; not for technics ( = /methods); see MeSH scope note in Introduction; indexing policy: Manual 19.4.35; DF: /instrum or /IS LT LQ SH*isolation & purification (Subheading) LA; ; ; ; MSUsed with bacteria, viruses, fungi, protozoa, and helminths for the obtaining of pure strains or for the demonstration of the presence of or identification of organisms by DNA analyses, immunologic, or other methods; includes culture technics. Also with biological substances and chemicals for the isolation and purification of the constituents. OLsearch policy: Online Manual; use: main heading/IP or IP (SH) or SUBS APPLY IP ANsubhead only; with micro-organisms & helminths includes obtaining pure strains, demonstrating presence & culture technics but consider also /growth & development; with chemicals & biological substances includes isolation of constituents; indexing policy: Manual 19.4.36; DF: /isol or /IP LT LQ SH*legislation & jurisprudence (Subheading) LA; ; ; ; ; MSUsed for laws, statutes, ordinances, or government regulations, as well as for legal controversy and court decisions. OLsearch policy: Online Manual; use: main heading/LJ or LJ (SH) or SUBS APPLY LJ ANsubhead only; includes ╥legal╙, ╥laws╙, ╥government regulations╙,╥statutes╙, ╥ordinances╙, ╥medicolegal╙, ╥judicial╙, ╥juridical╙, ╥suits╙, ╥avoidance of suits╙, ╥litigation╙, ╥court decisions╙; indexing policy: Manual 19.4.71; DF: /legis or /LJ LT LQ SH*manpower (Subheading) LA; ; ; ; ; ; ; ; ; ; MSUsed with disciplines and programs for the demand, supply, distribution, recruitment, and use of personnel. OLsearch policy: Online Manual; use: main heading/MA or MA (SH) or SUBS APPLY MA ANsubhead only; for availability of personnel only; see MeSH scope note in Introduction; indexing policy: Manual 19.4.37; DF: /man or /MA LT LQ SH*metabolism (Subheading) LA; ; ; ; ; ; ; ; ; ; MSUsed with organs, cells and subcellular fractions, organisms, and diseases for metabolism; with drugs and chemicals for absorption, distribution, and excretion. For biosynthesis, enzymology, and secretion use the specific subheadings. OLsearch policy: Online Manual; use: main heading/ME or ME (SH) or SUBS APPLY ME ANsubhead only; includes ╥absorption╙, ╥anabolism╙, ╥binding╙, ╥catabolism╙, ╥conversion╙, ╥degradation╙, ╥distribution╙, ╥incorporation╙, ╥mobilization╙, ╥pharmacokinetics╙, ╥release╙, ╥splitting╙, ╥storage╙, ╥transport╙, ╥turnover╙, ╥uptake╙, ╥utilization╙; for excretion into the blood use /blood, into the cerebrospinal fluid use /cerebrospinal fluid, into the urine use /urine; for biosynthesis or synthesis use /biosynthesis; for secretion use /secretion; for any metabolic aspect of enzymes use /enzymology; indexing policy: Manual 19.4.38; DF: /metab or /ME LT LQ SH*methods (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed with technics, procedures, and programs for methods. OLsearch policy: Online Manual; use: main heading/MT or MT (SH) or SUBS APPLY MT ANsubhead only; includes ╥technic╙, ╥methodology╙, ╥procedures╙; see also /instrumentation; indexing policy: Manual 19.4.39; DF: /methods or /MT LT LQ SH*microbiology (Subheading) LA; ; ; ; ; ; MSUsed with organs, animals and higher plants and with diseases for microbiologic studies. For parasites, ╥parasitology╙ is used. OLsearch policy: Online Manual; use: main heading/MI or MI (SH) or SUBS APPLY MI ANsubhead only; for bacteria, rickettsia, viruses, fungi & nonparasitic protozoa; for parasitic protozoa use /parasitology; for ability of organisms to cause disease use /pathogenicity; see MeSH scope note in Introduction; indexing policy: Manual 19.4.40; DF: /microbiol or /MI LT LQ SH*mortality (Subheading) LA; ; ; MSUsed with diseases for mortality statistics, and with procedures for deaths resulting from the procedure. OLsearch policy: Online Manual; use: main heading/MO or MO (SH) or SUBS APPLY MO ANsubhead only; includes ╥survival╙; see MeSH scope note in Introduction; indexing policy: Manual 19.4.41; DF: /mortal or /MO LT LQ SH*nursing (Subheading) LA; ; MSUsed with diseases for nursing care and technics in their management; includes the nursing role in diagnostic, therapeutic, and preventive procedures. OLsearch policy: Online Manual; use: main heading/NU or NU (SH) or SUBS APPLY NU ANsubhead only; includes ╥nursing care╙ by professional nurse or physician-prescribed home programs; see MeSH scope note in Introduction; indexing policy: Manual 19.4.42; DF: /nurs or /NU LT LQ SH*occurrence (Subheading) LA; ; ; MSUsed with diseases for incidence and prevalence; includes endemic and epidemic outbreaks; includes surveys and estimates of morbidity in geographic areas and in subdivisions of populations. Excludes mortality, for which ╥mortality╙ is used. OLsearch policy: Online Manual; use: main heading/OC or OC (SH) or SUBS APPLY OC ANsubhead only; includes ╥epidemiology╙, ╥statistics╙, ╥incidence╙, ╥outbreaks╙, ╥frequency╙, ╥prevalence╙, ╥morbidity╙; not for ╥mortality╙ ( = /mortality); see MeSH scope note in Introduction; indexing policy: Manual 19.4.43; DF: /occur or /OC LT LQ SH*organization & administration (Subheading) LA; ; ; ; MSUsed for administrative structure and management. OLsearch policy: Online Manual; use: main heading/OG or OG (SH) or SUBS APPLY OG ANsubhead only; includes organizational structure & management; indexing policy: Manual 19.4.72; DF: /organ or /OG LT LQ SH*parasitology (Subheading) LA; ; ; ; ; ; MSUsed with animals, higher plants, organs and diseases for parasitic factors; do not use if the parasitic involvement is implicit in the diagnosis. OLsearch policy: Online Manual; use: main heading/PS or PS (SH) or SUBS APPLY PS ANsubhead only; for parasitic protozoa & higher parasites; for non-parasitic protozoa use /microbiology; see MeSH scope note in Introduction; indexing policy: Manual 19.4.44; DF: /parasitol or /PS LT LQ SH*pathogenicity (Subheading) LA; ; ; MSUsed with microorganisms, viruses, and parasites for studies of their ability to cause disease in man or animals. OLsearch policy: Online Manual; use: main heading/PY or PY (SH) or SUBS APPLY PY ANsubhead only; for the potential ability of micro-organisms or parasites to cause disease in man or animal under specified conditions: not for specific infections; includes virulence; see MeSH scope note in Introduction; indexing policy: Manual 19.4.45; DF: /pathogen or /PY LT LQ SH*pathology (Subheading) LA; ; ; MSUsed for organ, tissue, or cell structure in disease states. OLsearch policy: Online Manual; use: main heading/PA or PA (SH) or SUBS APPLY PA ANsubhead only; for description of tissue or cell structure in disease: not for normal tissue ( = /anatomy & histology) nor for normal cells ( = /cytology); not a synonym for ╥disease╙; includes biopsy; for subcellular pathology use /ultrastruct; indexing policy: Manual 19.4.46; DF: /pathol or /PA LT LQ SH*pharmacodynamics (Subheading) LA MSUsed with drugs and exogenously administered chemical substances for their actions on tissues and organisms; includes effects upon metabolism, acceleration or inhibition of biological processes, and the mechanisms of action. OLsearch policy: Online Manual; use: main heading/PD or PD (SH) or SUBS APPLY PD ANsubhead only; includes ╥pharmacology╙, ╥mechanism of action╙, ╥mode of action╙; not for pharmacokinetics ( = /metabolism); see also /adverse effects, /poisoning & /toxicity; see MeSH scope note in Introduction; indexing policy: Manual 19.4.47; DF: /pharm or /PD LT LQ SH*physiology (Subheading) LA; ; ; ; ; ; ; ; ; ; MSUsed with organs, tissues, and cells of unicellular and multicellular organisms for normal function; used also with biochemical substances, endogenously produced, for their physiologic role. OLsearch policy: Online Manual; use: main heading/PH or PH (SH) or SUBS APPLY PH ANsubhead only; normal ╥function╙ only: for function in disease use /physiopathology; with endogenous chemicals only, for their physiologic role; see MeSH scope note in Introduction; indexing policy: Manual 19.4.48; DF: /physiol or /PH LT LQ SH*physiopathology (Subheading) LA; ; MSUsed with organs and diseases for disordered function in disease states. OLsearch policy: Online Manual; use: main heading/PP or PP (SH) or SUBS APPLY PP ANsubhead only; for function of organs in disease states only; not a synonym for ╥disease╙; indexing policy: Manual 19.4.49; DF: /physiopathology or /PP LT LQ SH*poisoning (Subheading) LA; MSUsed with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure. OLsearch policy: Online Manual; use: main heading/PO or PO (SH) or SUBS APPLY PO ANsubhead only; for clinical & veterinary only; for human & animal experiments use /toxicity; see also /adverse effects & /toxicity; see MeSH scope note in Introduction; indexing policy: Manual 19.4.50; DF: /pois or /PO LT LQ SH*prevention & control (Subheading) LA; ; ; ; MSUsed with disease headings for increasing human or animal resistance against disease, (e.g. immunization); for control of transmission agents; for prevention and control of environmental hazards; for prevention and control of social factors leading to disease; includes preventive measures in individual cases. OLsearch policy: Online Manual; use: main heading/PC or PC (SH) or SUBS APPLY PC ANsubhead only; includes ╥preventive therapy╙; includes vaccination; for prevention on epidemiologic or personal level; see MeSH scope note in Introduction; indexing policy: Manual 19.4.51; DF: /prev or /PC LT LQ SH*psychology (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed with non-psychiatric disease, technics, and named groups for psychologic, psychiatric, psychosomatic, psychosocial, behavioral, and emotional aspects, and with psychiatric disease for psychologic aspects. OLsearch policy: Online Manual; use: main heading/PX or PX (SH) or SUBS APPLY PX ANsubhead only; includes ╥psychiatric╙, ╥psychosomatic╙, ╥psychogenic╙, ╥emotional╙, ╥affective╙, ╥behavioral╙; see MeSH scope note in Introduction; indexing policy: Manual 19.4.73; DF: /psychol or /PX LT LQ SH*radiation effects (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed for effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes; includes effect of irradiation on drugs and chemicals. OLsearch policy: Online Manual; use: main heading/RE or RE (SH) or SUBS APPLY RE ANsubhead only; includes ionizing & non-ionizing radiation; not for therapeutic effect of radiations ( = /radiotherapy); see MeSH scope note in Introduction; indexing policy: Manual 19.4.52; DF: /rad eff or /RE LT LQ SH*radiography (Subheading) LA; MSUsed with organs, regions, and diseases for x-ray examinations. Does not include radionuclide imaging for which ╥radionuclide imaging╙ is used. OLsearch policy: Online Manual; use: main heading/RA or RA (SH) or SUBS APPLY RA ANsubhead only; includes ╥x-ray diagnosis╙, ╥roentgenography╙; not for radioisotope scanning ( = /radionuclide imaging); indexing policy: Manual 19.4.53; DF: /radiogr or /RA LT LQ SH*radionuclide imaging (Subheading) LA; MSUsed for radionuclide imaging of any anatomical structure, or for the diagnosis of disease. OLsearch policy: Online Manual; use: main heading/RI or RI (SH) or SUBS APPLY RI ANsubhead only; includes ╥radioisotope scanning╙; see MeSH scope note in Introduction; indexing policy: Manual 19.4.74; DF: /radionuclide or /RI LT LQ SH*radiotherapy (Subheading) LA MSUsed with disease headings for the therapeutic use of ionizing and nonionizing radiation; includes use of radioisotope therapy. OLsearch policy: Online Manual; use: main heading/RT or RT (SH) or SUBS APPLY RT ANsubhead only; includes x-ray, radioisotope, other ionizing radiation & non-ionizing radiation; indexing policy: Manual 19.4.54; DF: /radiother or /RT LT LQ SH*rehabilitation (Subheading) LA; ; MSUsed with diseases and surgical procedures for restoration of function of the individual. OLsearch policy: Online Manual; use: main heading/RH or RH (SH) or SUBS APPLY RH ANsubhead only; for restoration of patient to pre-disease or pre-therapy state; for ╥re-education╙ in French; indexing policy: Manual 19.4.55; DF: /rehabil or /RH LT LQ SH*secondary (Subheading) LA MSUsed to indicate the secondary location to which the neoplastic process has metastasized. OLsearch policy: Online Manual; use: main heading/SC or SC (SH) or SUBS APPLY SC ANsubhead only; for cancer only; includes ╥metastatic cancer╙ but not ╥cancer metastasizing to╙ ( = /pathology + NEOPLASM METASTASIS); see MeSH scope note in Introduction; indexing policy: Manual 19.4.76; DF: /second or /SC LT LQ SH*secretion (Subheading) LA; ; MSUsed for the discharge across the cell membrane, into the intracellular space or ducts, of endogenous substances resulting from the activity of intact cells of glands, tissues, or organs. OLsearch policy: Online Manual; use: main heading/SE or SE (SH) or SUBS APPLY SE ANsubhead only; for the act or function of secreting: not for ╥secretions╙; see MeSH scope note in Introduction; indexing policy: Manual 19.4.56; DF: /secret or /SE LT LQ SH*standards (Subheading) LA; ; ; ; ; ; ; ; ; ; MSUsed with facilities, personnel, and program headings for the development, testing, and application of standards of adequacy or acceptable performance, used with chemicals and drugs for standards of identification, quality, and potency; includes health or safety standards in industries and occupations. OLsearch policy: Online Manual; use: main heading/ST or ST (SH) or SUBS APPLY ST ANsubhead only; for standards in testing & performance of programs & procedures; with drugs for standards in assay technics, quality & potency; see MeSH scope note in Introduction; indexing policy: Manual 19.4.57; DF: /stand or /ST LT LQ SH*supply & distribution (Subheading) LA; ; ; ; ; ; ; ; ; MSUsed for the quantitative availability and distribution of material, equipment, health services, and facilities. Excludes food supply and water supply in industries and occupations. OLsearch policy: Online Manual; use: main heading/SD or SD (SH) or SUBS APPLY SD ANsubhead only; includes ╥availability╙; for personnel, services & facilities; for drugs; not for food ( = FOOD SUPPLY) nor for water ( = WATER SUPPLY); see MeSH scope note in Introduction; indexing policy: Manual 19.4.58; DF: /supply or /SD LT LQ SH*surgery (Subheading) LA; ; ; MSUsed for operative procedures on organs, regions, or tissues in the treatment of diseases; includes tissue section by lasers. Excludes transplantation, for which ╥transplantation╙ is used. OLsearch policy: Online Manual; use: main heading/SU or SU (SH) or SUBS APPLY SU ANsubhead only; includes ╥operation╙, ╥surgical therapy╙; for tissue section or coagulation by laser; not for transplantation ( = /transplantation); indexing policy: Manual 19.4.59; DF: /surg or /SU LT LQ SH*therapeutic use (Subheading) LA; MSUsed with drugs, biological preparations, and physical agents for their use in the prophylaxis and treatment of disease; includes veterinary use. OLsearch policy: Online Manual; use: main heading/TU or TU (SH) or SUBS APPLY TU ANsubhead only; for treatment or preventive use of drugs or physical agents in clinical or experimental human or animal disease; indexing policy: Manual 19.4.60; DF: /ther use or /TU LT LQ SH*therapy (Subheading) LA; MSUsed with diseases for therapies except drug therapy, diet therapy, radiotherapy, and surgery, for which subheadings exist; also to be used for articles dealing with multiple therapies. OLsearch policy: Online Manual; use: main heading/TH or TH (SH) or SUBS APPLY TH ANsubhead only; for general or unspecified therapy & multiple therapies; for immunotherapy, tissue therapy & therapy with biological products; not for drug therapy ( =/drug therapy), nor for diet therapy ( = /diet therapy), nor for surgical therapy ( = /surgery), nor for radiotherapy ( = /radiotherapy), nor for rehabilitative therapy ( = /rehabilitation); indexing policy: Manual 19.4.61; DF: /ther or /TH LT LQ SH*toxicity (Subheading) LA; MSUsed with drugs and chemicals for experimental human and animal studies of their ill effects; includes studies to determine the margin of safety or the reactions accompanying administration at various dose levels; used also for experimental studies of exposure to environmental agents. OLsearch policy: Online Manual; use: main heading/TO or TO (SH) or SUBS APPLY TO ANsubhead only; for experimental human & animal studies; includes margin of safety & experimental exposure to environmental agents; see also /adverse effects & /poisoning; see MeSH scope note in Introduction; indexing policy: Manual 19.4.62; DF: /tox or /TO LT LQ SH*transmission (Subheading) LA MSUsed with diseases for studies of the modes of transmission. OLsearch policy: Online Manual; use: main heading/TM or TM (SH) or SUBS APPLY TM ANsubhead only; for transmission & mechanism of transmission of disease from man to man, from man to animal, from animal to man or animal to animal; indexing policy: Manual 19.4.63; DF: /transm or /TM LT LQ SH*transplantation (Subheading) LA MSUsed with organs, tissues, or cells for transplantation from one site to another within the same subject, or from one subject to another of the same species or different species. OLsearch policy: Online Manual; use: main heading/TR or TR (SH) or SUBS APPLY TR ANsubhead only; includes ╥grafts╙ & ╥grafting╙ from one site to another in the same subject, from one to another of same species, from one to another of a different species; indexing policy: Manual 19.4.64; DF: /transpl or /TR LT LQ SH*trends (Subheading) LA; ; ; ; ; ; ; MSUsed for the manner in which a subject changes, qualitatively or quantitatively, with time, whether past, present, or future. Excludes discussions of the course of disease in particular patients. OLsearch policy: Online Manual; use: main heading/TD or TD (SH) or SUBS APPLY TD ANsubhead only; includes ╥forecasting╙ & ╥futurology╙; for a continuum from past to present, present to future; see MeSH scope note in Introduction; indexing policy: Manual 19.4.75; DF: /trends or /TD LT LQ SH*ultrastructure (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed with tissues and cells (including neoplasms) and microorganisms for microanatomic structures, generally below the size visible by light microscopy. OLsearch policy: Online Manual; use: main heading/UL or UL (SH) or SUBS APPLY UL ANsubhead only; for normal or pathological subcellular structure; see MeSH scope note in Introduction; indexing policy: Manual 19.4.65; DF: /ultrastruct or /UL LT LQ SH*urine (Subheading) LA; ; ; ; ; ; ; ; ; MSUsed for the presence or analysis of substances in the urine; also for the examination of, or changes in, the urine in diseases. OLsearch policy: Online Manual; use: main heading/UR or UR (SH) or SUBS APPLY UR ANsubhead only; for ╥in urine╙ or ╥urine in╙ animals or diseases; includes the presence of cells & endogenous & exogenous chemical substances; not for the presence of microbes or parasites in the urine in disease ( = /microbiology or /parasitology); see MeSH scope note in Introduction; indexing policy: Manual 19.4.66; DF: /urine or /UR LT LQ SH*utilization (Subheading) LA; ; ; ; ; ; ; ; MSUsed with equipment, facilities, programs, services, and health personnel for discussions, usually with data, of how much they are used. Includes discussions of overuse and underuse. OLsearch policy: Online Manual; use: main heading/UT or UT (SH) or SUBS APPLY UT ANsubhead only; not for ╥use╙ of procedures in treating or diagnosing patients; only for how much equipment, facilities, services & personnel are used, underused, overused or abused; indexing policy: Manual 19.4.67; DF: /util or /UT LT LQ SH*veterinary (Subheading) LA; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; MSUsed for naturally occurring diseases in animals, or for diagnostic, preventive, or therapeutic procedures used in veterinary medicine. OLsearch policy: Online Manual; use: main heading/VE or VE (SH) or SUBS APPLY VE ANsubhead only; for pets & domestic, wild & zoo animals in veterinary medicine; for laboratory animals only if of concern to the veterinarian, not as experimental animals; see MeSH scope note in Introduction; indexing policy: Manual 19.4.68; DF: /vet or /VE LT LQ MSAn ionophorous antibiotic from Streptomyces chartreusensis. It binds and transports cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. PM84; was see under ANTIBIOTICS 1975-83 HN84(75); was see under ANTIBIOTICS 1975-83 MHÑA-23187 ANdo not use /defic /physiol RN52665-69-7 PIAntibiotics (73-74); Carboxylic Acids (73-74) MND8.373.936.500.25; D20.85.10 LH HN(72) MHÑAbate ANdo not use /biosyn /defic /physiol; TN 111 for eff on insects RN3383-96-8 PIInsecticides (66-71) MND2.719.27; D5.723.491.657.31 DMÑInsecticides, Organothiophosphate LH LM MSPlaces where animals are slaughtered and dressed for market. MHÑAbattoirs ANonly /econ /hist /stand MNJ1.576.598.256 XSSLAUGHTERHOUSES LH LS MSShortened forms of written words or phrases used for brevity. MHÑAbbreviations ANincludes acronyms; IM; no qualif CATALOG: /form /lang MNL1.143.506.598.400.556.131 LH MHÑAbdomen ANregion & abdominal organs (tend to prefer specific organs); not for rectus abdominis & other abdom muscles (index under ABDOMINAL WALL); /inj = ABDOMINAL INJURIES; abdominal pain = ABDOMEN (IM) + PAIN (IM); abrupt dis requiring emerg surg = ABDOMEN, ACUTE MNA1.47 LH MSClinical syndrome characterized by abdominal pain of great severity associated with other symptoms and signs, usually those of acute peritonitis, which might well be the result of a ruptured abdominal viscus or a similar abdominal catastrophe requiring urgent surgical operation. MHÑAbdomen, Acute ANabrupt abdom dis requiring emerg surg MNC23.304.61 LH MHÑAbdominal Injuries ANgeneral term for inj of organs in the abdom cavity; prefer specific organs /inj MNC21.866.17 LH MHÑAbdominal Neoplasms ANgeneral term for neopl of organs in the abdom cavity; prefer specific organ/neopl terms; /anal /blood supply /secret /ultrastruct permitted; coord IM with histol type of neopl if given (IM) MNC4.588.33 LH MHÑAbdominal Wall ANrectus abdominis & other abdom muscles go here; hernia = HERNIA, VENTRAL MNA2.633.61; A2.633.740.61 LH OLuse ABDUCENS NERVE to search ABDUCENT NERVE back thru 1966 PM77; was ABDUCENT NERVE 1963-76 HN77; was ABDUCENT NERVE 1963-76 MHÑAbducens Nerve AN6th cranial nerve; do not use /innerv; neopl: coord IM with CRANIAL NERVE NEOPLASMS (IM) + histol type of neopl (IM) MNA8.796.214.44 LH MSA defective murine leukemia virus capable of transforming lymphoid cells and producing a rapidly progressing lymphoid leukemia after superinfection with Friend, Moloney or Rauscher virus. HN(80) MHÑAbelson Leukemia Virus ANdo not use /blood-csf-urine /cytol; infection: coord NIM with LEUKEMIA, EXPERIMENTAL (IM) PIMouse Leukemia Viruses (66-79) MNB4.909.574.807.674.632.41; B4.909.777.731.674.632.41; B4.909.777.779.674.632.41 DMÑMouse Leukemia Viruses LH LM PM66 HN66(64) MHÑAbetalipoproteinemia ANdo not confuse with HYPOBETALIPOPROTEINEMIA MNC10.228.140.163.47; C15.378.147.68; C18.452.648.556.485.131 XSBASSEN-KORNZWEIG SYNDROME LH LS MSCongenital malformations of organs or parts; includes the field of teratology. Use for general material; for abnormalities of a specific part use the subheading ╥Abnormalities╙ after the name of the part. MHÑAbnormalities ANGEN only: prefer /abnorm: Manual 19.5+; /chem ind = ABNORMALITIES, DRUG-INDUCED; do not use /compl /congen; policy: Manual 23.26+; TN 109: relation to /congen & INFANT, NEWBORN, DISEASES MNC16.131 XSBirth Defects; Congenital Defects; DEFORMITIES FXÑFetal Diseases LH LS; ; LX MSCongenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother or to which she is inadvertently exposed during the manufacture of such substances. Excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.